Getting a high score rank in Resident Evil 2 isn’t as cryptic as one might think. Okay, to be more precise, the conditions are rather simplistic. Finish the game as fast as possible. And no, I’m not joking. There’s very little few that also factor into getting that S+ rank. Such things are:
The number of saves you have.
How many times you used the First Aid Spray.
Although, first aid spray does seem to affect the score, the usage of herbs has very little effect on it. So feel free to use it when you need to as dying will only lengthen play time.
There are quite a few reasons for wanting to get an S+ rank. The unlockables are quite tempting for anybody who wants that infinite ammo for specific guns. Needless to say, the higher your rank is, the more the rewards. And if you want to get that S+ ranking, you’d have to complete Leon/Claire’s scenario with the following conditions:
Clear within 2 and a half hours for Scenario A and 2 hours for Scenario B.
Number of Saves must be less than 3.
No infinite ammo weapons, including infinite survival knife.
Well, that sounds difficult, doesn’t it? Despite having only three conditions, S+ ranking is nevertheless a challenge. If you do die, I’d recommend just going back to the main menu and loading a previous save. Because continuing counts towards your total Resident Evil 2 gameplay. What you unlock also depends on what difficulty you’re playing it on.
And that’s about all I got for you. Well, good luck!